Abstract
BackgroundMelanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. This study aimed to describe a case of distinctive melanotic Xp11 TRC and to elucidate its clinicopathological and molecular genetic features.Case presentationA 44-year-old Chinese female presented with a left renal mass. Abdominal ultrasonography and computed tomography (CT) scans revealed a 4.5 cm × 4.0 cm mass in the left kidney. Grossly, the well-demarcated mass was black with moderately firm consistency. Microscopic examination indicated that the tumor was characterized by the presence of nests and cords of polygonal cells with clear and granular eosinophilic cytoplasm, central round to oval nuclei and occasional nucleoli. Intracytoplasmic melanin was observed in approximately 45% of tumor cells. Uniquely, the tumor presented with intranuclear eosinophilic pseudoinclusions and thick-walled stromal blood vessels. IHC showed that tumor cells were diffusely positive for TFE3 and exhibited patchy and weak HMB45 staining. FISH confirmed the presence of TFE3 rearrangement.ConclusionThis case is the twentieth published case of melanotic Xp11 TRC. Moreover, the present patient had a favorable prognosis given that she was disease free at her 113-month postoperative follow-up. Our case adds to the small body of literature on these exceptionally rare tumors and widens their clinicopathological spectrum.
Highlights
Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial
Our case adds to the small body of literature on these exceptionally rare tumors and widens their clinicopathological spectrum
Melanotic Xp11 translocation renal cancer (TRC) is a newly defined entity that is characterized by sheets and nests of epithelioid neoplastic cells with clear to finely granular eosinophilic cytoplasm and intracytoplasmic melanin; immunohistochemical positivity for melanocytic markers but negativity for epithelial and muscular markers; and rearrangement of the transcription factor enhancer 3 (TFE3) gene
Summary
Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. Melanotic Xp11 translocation renal cancer (TRC) is a newly defined entity that is characterized by sheets and nests of epithelioid neoplastic cells with clear to finely granular eosinophilic cytoplasm and intracytoplasmic melanin; immunohistochemical positivity for melanocytic markers (such as HMB45 and Melan A) but negativity for epithelial and muscular markers; and rearrangement of the transcription factor enhancer 3 (TFE3) gene. Since it was first described by Argani et al in 2009, only 19 cases of melanotic Xp11 TRC have been documented in English-language publications (Table 1) [1,2,3,4,5,6,7,8,9,10,11].
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