Abstract
This thesis investigated the role of rod, cone and melanopsin photoreceptors in mediating human brightness perception across the natural operating range of the eye. In scotopic illumination, brightness perception is initiated by rod signals transmitted to higher brain centres via conventional retinogeniculate and melanopsin pathways. In mesopic illumination, melanopsin photoreception begins to scale brightness perception. In photopic illumination, melanopsin and cone luminance signals combine to mediate light hypersensitivity (photophobia) in healthy controls and migraineurs. These findings advance understanding of the relative photoreceptor contributions to human vision and guide the development of lighting technologies for individuals who experience disease-related photophobia.
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