Abstract
Melanoma Genetics/Genomics
Highlights
The present volume aims to provide the reader with a snapshot of current genetic and genomic investigations of melanoma, with special emphasis on targeted treatments, and personalized medicine
A collection of Opinion, Review, Primary Research, Hypothesis and Theory, and Methods articles has been assembled that describes the panoply of genes, therapeutic targets, biomarkers, genetic pathways, and pathogenic mechanisms involved in melanoma onset and metastasis, and of clinical outcomes in patient in response to chemotherapy, immunotherapy, and personalized treatment options
Mutations in genes like GNAQ, GNA11, and BAP1 are associated with uveal melanoma or blue nevi, and for the first time Hawkes et al (4) have investigated in their Original Research Article whether inherited mutations in these genes are associated with familial predisposition to uveal melanoma or blue nevi
Summary
The present volume aims to provide the reader with a snapshot of current genetic and genomic investigations of melanoma, with special emphasis on targeted treatments, and personalized medicine. A collection of Opinion, Review, Primary Research, Hypothesis and Theory, and Methods articles has been assembled that describes the panoply of genes, therapeutic targets, biomarkers, genetic pathways, and pathogenic mechanisms involved in melanoma onset and metastasis, and of clinical outcomes in patient in response to chemotherapy, immunotherapy, and personalized treatment options.
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