Abstract
In tumors, traditional angiogenesis is observed in addition to vascular channels that lack endothelial cell lining. It is assumed that the network of such channels compensates for the insufficiently development of the blood circulatory system in the tumor and prevents early necrosis inside the tumor. A strong statistical correlation established between the presence of vascular channels in the tumor and the low survival rate of patients confirms this hypothesis. In the light of these data, the search for a low-molecular inhibitor of vascular channels formation in a tumor becomes extremely relevant. This review discusses the functional and prognostic significance of vasculogenic mimicry. Particular attention is paid to the optimization of the in vitro vasculogenic mimicry model based on the analysis of 11 melanoma cell lines obtained from metastases of patients with disseminated melanoma. In addition, the development of an in vivo vasculogenic mimicry model is being discussed.
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