Abstract
MELANOGENS are tyrosine derivatives, or water soluble, colorless chromogens convertible into melanin in the presence of oxygen. These chromogens are present in sufficient quantities in the urine of some patients with malignant melanoma to cause a deep brown and later a black color transformation of the urine when exposed to air for several hours. Such color transformation or darkening of urine is not a sufficiently consistent observation to be of great value in diagnosis, in judging completeness of removal after surgical treatment, or in early detection of recurrences in patients with malignant melanoma. Several simple laboratory procedures are widely used for these purposes; we have evaluated the more common of these. Materials and Methods Fresh urine specimens sent to the laboratory for routine examination were used for controls. Urine from 12 patients with histologically verified malignant melanoma known to be present at the time of collection was also examined. All
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