Abstract
Vertebrate pigmentation is a process directed by various transcriptional regulators, that drive the specification of melanoblasts from neural crest cells, their proliferation and migration, and terminal differentiation into melanocytes, culminating in the generation of pigment and it's distribution to surrounding keratinocytes. The transcription factor MITF has been coined the “master regulator” of melanocyte development (reviewed in (Steingrimsson, Copeland and Jenkins, 2004)), as it drives both the specification and differentiation of melanocytes. It is associated with pigmentation disorders in human, and Mitf mutant mice have a varying degree of pigmentation defects. This article is protected by copyright. All rights reserved.
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