Abstract
Chromosome rearrangement breakpoints are not uniformly found throughout the genome (Lupski, 2004) and certain genomic regions, especially subtelomeric and pericentromeric regions (Shaw and Lupski, 2004) are more likely to be involved in a chromosomal rearrangement. This clustering of chromosomal rearrangements around hotspots creates considerable genomic instability (Shaw and Lupski, 2004). Such regions of genomic instability involve low copy repeats (LCRs).
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