Abstract
Meiosis, an essential step in gametogenesis, is the key event in sexually reproducing organisms. Thousands of genes have been reported to be involved in meiosis. Therefore, a specialist database is much needed for scientists to know about the function of these genes quickly and to search for genes with potential roles in meiosis. Here, we developed “MeiosisOnline,” a publicly accessible, comprehensive database of known functional genes and potential candidates in meiosis (https://mcg.ustc.edu.cn/bsc/meiosis/index.html). A total of 2,052 meiotic genes were manually curated from literature resource and were classified into different categories. Annotation information was provided for both meiotic genes and predicted candidates, including basic information, function, protein–protein interaction (PPI), and expression data. On the other hand, 165 mouse genes were predicted as potential candidates in meiosis using the “Greed AUC Stepwise” algorithm. Thus, MeiosisOnline provides the most updated and detailed information of experimental verified and predicted genes in meiosis. Furthermore, the searching tools and friendly interface of MeiosisOnline will greatly help researchers in studying meiosis in an easy and efficient way.
Highlights
Meiosis, the process to generate daughter cells with an intact, haploid genome through one round of DNA replication followed by two rounds of cell division, is a basic feature of sexual reproductive organisms (Gerton and Hawley, 2005; Miller et al, 2013; Bolcun-Filas and Handel, 2018; Biswas et al, 2021)
With the development of genomic technologies on model organisms and recent advances of transcriptomics and proteomics, tremendous articles have been published on meiosis from different species, and we get a clearer understanding about the genetic control of key events in MeiosisOnline Tracking and Predicting Meiotic Genes meiosis (Watanabe et al, 2001; Wang et al, 2009; Chalmel and Rolland, 2015; Chen et al, 2018)
We found that the functional meiotic genes are firstly derived from mice, which accounts for 28.74% of the total reported genes, followed by human (5.16%) and rat (5.07%)
Summary
The process to generate daughter cells with an intact, haploid genome through one round of DNA replication followed by two rounds of cell division, is a basic feature of sexual reproductive organisms (Gerton and Hawley, 2005; Miller et al, 2013; Bolcun-Filas and Handel, 2018; Biswas et al, 2021). Meiosis is characterized by homologous chromosome separation, which ensures the genetic integrity of all daughter cells (Sato et al, 2021). A series of biological processes would take place during meiosis prophase I to guarantee the formation and repair of programmed meiotic DNA double-strand breaks (DSBs) and the pair and synapsis between homologous chromosomes, as well as the formation of meiotic crossovers (Handel and Schimenti, 2010; Baudat et al, 2013; Gray and Cohen, 2016; Ranjha et al, 2018; Jiao et al, 2020; Li et al, 2021). It is still challenging to identify novel meiotic genes, especially in mammalian meiosis, since genetic modification in model organisms is time-consuming and is like a gamble sometimes (Khan et al, 2018, 2020; Huang et al, 2019; Xie et al, 2019; Yousaf et al, 2020). A specialist database that can provide integrated annotation of meiotic genes and predict novel functional genes is urgently needed
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