Abstract
Abstract Because of the multitude of cortical lesions in tuberous sclerosis, identifying the epileptogenic tubers is difficult and often requires invasive intracranial electroencephalographic (EEG) monitoring. We report on a patient suffering from focal epilepsy symptomatic to tuberous sclerosis upon whom the MEG technique “Synthetic Aperture Magnetometry (SAM)” with excess kurtosis (g2) analysis was performed for the localization of the epileptogenic zone. Simultaneous EEG and MEG source localization data were superimposed on the MRI images, and compared with the fluid-attenuated inversion recovery (FLAIR) MRI sequences. Despite the multiple tubers on FLAIR–MRI, SAM(g2) analysis demonstrated clear left anterior temporal focus corresponding to a single large tuber. Seizure semiology corresponded well with the zone of epileptic activity delineated by MEG and SAM(g2). We suggest that magnetoencephalography with SAM(g2) analysis may be of clinical importance for the accurate identification of epileptogenic tubers in patients with tuberous sclerosis.
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