Abstract
Imeglimin is a new class of drug which has introduced recently. The molecular mechanisms are unknown, although imeglimin improves insulin sensitivity in humans. Pre-clinical studies had confirmed that imeglimin favouring lipid oxidation in liver and preserving mitochondrial function from oxidative stress, therefore normalizes glucose tolerance and insulin sensitivity. The main objective of this review article is to highlight updates of new class of drug which is imeglimin and generated a huge interest after recently conducted EASD at Barcelona.
Highlights
Diabetes mellitus represents a series of metabolic conditions associated with hyperglycemia and caused by defects in insulin secretion and/or insulin action
Primary objectives of the study were confirmed by analyzing blood parameters such as Fasting Blood Glucose, HbA1c and Insulin Resistance
At the end of the study period mean fasting blood glucose (FBG) for those treated with 2.5 g of Collagen peptides (CPT) decreased from 229 ± 75.2 mg/dL to 194 ± 60.4 mg/dL (p>0.05) and for those treated with g CPT the FBG decreased from 188 ± 28.6 mg/dL to 110.10 ± 15.4 mg/dL (p
Summary
Diabetes mellitus represents a series of metabolic conditions associated with hyperglycemia and caused by defects in insulin secretion and/or insulin action. GIP and GLP-1 are rapidly degraded after secretion by the action of DPP-4, resulting in loss of their insulinotropic activities [2]. The use of DPP4 inhibitors for elongation of the half-life of incretins, especially GLP-1, is a therapeutic approach for managing T2DM [3]. The ubiquitously expressed enzyme DPP-4 (EC 3.4.14.5) modulates the biological activity of circulating peptide hormones by cleaving the two N-terminal amino acids X-Pro and X-Ala [4], and metabolizes insulinotropic hormone glucagon-like peptide-1 (GLP-1). DPP-4 inhibitors that protect active GLP-1 from being cleaved by DPP-4 can be used to control postprandial glycemia in T2DM [5,6]
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