Megastigmane and abscisic acid glycosides from the leaves of Laurus nobilis L.

Abstract

Two new megastigmane glycosides, laurusides E-F (1 and 3) and three known ones (2, 5, and 7), together with a new abscisic acid glycoside, lauruside G (4) and a known one (6), were isolated from a methanolic extract of Laurus nobilis L. leaves using various chromatographic techniques. The structures of these compounds were fully characterized using a combination of spectroscopic techniques including multinuclear and multidimensional NMR and mass spectrometry. All of the isolates were evaluated for their inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 cells.