Megastigmane and 7,9′-dinorlignan glycosides from the tubers of Stephania kaweesakii

Abstract

Two isomers of megastigmane glycosides, (6 R , 9 S )-blumenol C 9- O -gentibioside ( 2 ) and (6 S , 9 S )-blumenol C 9- O -gentiobioside ( 3 ), and a new 7,9′-dinorlignan glycoside, stepdonorlignoside ( 4 ) were isolated from the tubers of Stephania kaweesakii . The structure determinations were considered based on the physical data and spectroscopic evidence. The absolute configurations of two megastigmanes were determined for the first time. Additionally, ten known compounds were isolated: (6 R , 9 S )-blumenol C 9- O -β- D -glucopyranoside, (+)-isolariciresinol 3a- O -β- D -glucopyranoside, salidroside, N - trans -caffeoyltyramine, ( R )-isococlaurine, ( R )-isococlaurine 4′- O - β -glucopyranoside, (−)-oblongine, (+)-magnocurarine, fordianoside, and (−)-cyclanoline. • (6 R , 9 S ) and (6 S , 9 S )-Isomers of blumenol C 9- O -gentibiosides were isolated. • A new 7,9′-dinorlignan glycoside was isolated from Stephania kaweesakii . • The configurations of blumenol C 9- O -gentiobiosides were determined for the first time.