Abstract
Here we present an ultrahigh-speed Fourier-domain optical coherence tomography (OCT) that records the OCT spectrum in streak mode with a high-speed area scan camera, which allows higher OCT imaging speed than can be achieved with a line-scan camera. Unlike parallel OCT techniques that also use area scan cameras, the conventional single-mode fiber-based point-scanning mechanism is retained to provide a confocal gate that rejects multiply scattered photons from the sample. When using a 1000 Hz resonant scanner as the streak scanner, 1,016,000 A-scans have been obtained in 1 s. This method's effectiveness has been demonstrated by recording in vivo OCT-image sequences of embryonic chick hearts at 1000 frames/s. In addition, 2-megahertz OCT data have been obtained with another high speed camera.
Highlights
Much research has been devoted to increasing the imaging speed and resolution of optical coherence tomography (OCT)
We have demonstrated the design of a resonant scanner-based streak-mode Fourier domain OCT (FD-OCT) and its application in ultrahigh-speed biological tissue imaging
In this technique, we have shown that the effect of the streak scanning is the change of the integration time window from rect(t/T ) in conventional FD-OCT to prolonged H (t) in streak mode FD-OCT
Summary
Much research has been devoted to increasing the imaging speed and resolution of optical coherence tomography (OCT). We report streak-mode Fourier domain optical coherence tomography (SM-FDOCT), a technique in which an areascan camera is used instead of a line-scan camera to record the OCT spectrum. This SM-FDOCT retains the conventional point-scanning mechanism so that the small aperture of the single-mode fiber functions as a confocal gate for rejecting multiply scattered photons. While the probe beam is scanning the sample laterally, the corresponding OCT spectrum is physically scanned on the area-scan camera using a streak scanner, which can be, for example, a galvano mirror, a resonant mirror, a polygonal mirror, an acoustic- or electro-optic deflector. A variable neutral density filter is placed in the reference arm to adjust the intensity of the reference beam for optimizing the system sensitivity.[13,14] A fiber-pigtailed diode laser, which has 1 mW output at 633 nm, is used as a marker laser to visualize the focal point of the probe beam within the sample
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