Abstract
Event Abstract Back to Event MEG responses to sound in guinea pig and mouse Alain De Cheveigné1*, Jennifer Linden2, Maria Chait2, Björn Christianson2, David McAlpine2, Gen Uehara3, Yoshiaki Adachi3, Jun Kawai3, Masakazu Miyamoto3 and Hisashi Kado3 1 CNRS/ENS/Université Paris Descartes, France 2 UCL Ear Institute, United Kingdom 3 KIT Applied Electronics Laboratory, Japan Using a newly developed magnetoencephalograph (MEG) for small animals, we have recorded auditory-evoked cortical responses non-invasively in both guinea pig and mouse. The small-animal MEG system has 9 magnetometers placed in an 8x8 mm square array at 3 mm from the outer surface of the liquid helium-filled dewar. An additional set of 3 magnetometers and one accelerometer are used to measure and suppress environmental noise. Sound is delivered either free-field, or via short tubes from Etymotics transducers. Signal processing is crucial to extract the tiny brain responses from noise, and several new techniques have been developed for that purpose. Using these techniques, we can detect cortical responses evoked by sound onsets, transitions and binaural disparities in tone, noise and chirp stimuli, in both guinea pigs and mice. Up to 4 distinct spatio-temporal response components have been observed in these datasets. Additionally, we demonstrate that stimulus-specific adaptation (SSA), hypothesized to be a neural correlate of mismatch negativity (MMN), can be observed in MEG responses to deviant events within trains of standards, and we compare these responses to similar responses observed in humans. These results pave the way for joint MEG and electrophysiology in the same animals to elucidate the neural basis of the MEG response to sound, bridging the gap between human brain imaging and invasive animal electrophysiology. Supported by: CNRS, Wellcome Trust, European Union Marie Curie grant, Kanazawa Institute of Technology, Hokuriku Innovation Cluster for Health Science. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Instrumentation and Multi-modal Integrations: MEG, Low-field MRI,EEG, fMRI,TMS,NIRS Citation: De Cheveigné A, Linden J, Chait M, Christianson B, McAlpine D, Uehara G, Adachi Y, Kawai J, Miyamoto M and Kado H (2010). MEG responses to sound in guinea pig and mouse. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00428 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Apr 2010; Published Online: 09 Apr 2010. * Correspondence: Alain De Cheveigné, CNRS/ENS/Université Paris Descartes, Paris, France, alain.de.cheveigne@ens.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alain De Cheveigné Jennifer Linden Maria Chait Björn Christianson David McAlpine Gen Uehara Yoshiaki Adachi Jun Kawai Masakazu Miyamoto Hisashi Kado Google Alain De Cheveigné Jennifer Linden Maria Chait Björn Christianson David McAlpine Gen Uehara Yoshiaki Adachi Jun Kawai Masakazu Miyamoto Hisashi Kado Google Scholar Alain De Cheveigné Jennifer Linden Maria Chait Björn Christianson David McAlpine Gen Uehara Yoshiaki Adachi Jun Kawai Masakazu Miyamoto Hisashi Kado PubMed Alain De Cheveigné Jennifer Linden Maria Chait Björn Christianson David McAlpine Gen Uehara Yoshiaki Adachi Jun Kawai Masakazu Miyamoto Hisashi Kado Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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