MEG findings in a family with a clinical history of febrile seizures

Abstract

Event Abstract Back to Event MEG findings in a family with a clinical history of febrile seizures Athanasia Kotini1*, Aggelos Tsalkidis2, Photios Anninos1 and Athanasios Chatzimichael2 1 Democritus University of Thrace, Alex/polis, Lab of Medical Physics, Medical School, Greece 2 Democritus University of Thrace, Alex/polis, Dept of Pediatrics,Medical School, Greece Objective: Seizures of any type are usually a manifestation of a number of underlying pathologic conditions. To differentiate between them, careful history, physical examination, and laboratory work-up are usually required. EEG's and neuroimaging studies should be performed as routine ordering studies, while EEG's have been found to have limited value [1]. Methods: Our study population included 4 sisters within the age range of 2 - 5 years with a family history of febrile seizures. The MEG data were recorded with a 122-channel biomagnetometer. Equivalent current dipoles (ECDs) were calculated for epileptic spikes on MEG recordings according to the single dipole model. Results: One out of 4 children showed ECD dipoles located at the right - temporal lobe, as active region responsible for febrile seizures. Conclusions: We tried to find a procedure that can provide us with a prognostic indicator for possible epileptic behavior in children who experienced febrile seizures. We think that one of the prognostic indicators might be the existence of ECDs.