Abstract
Abstract NeuroPace has developed an experimental therapy for epilepsy that utilizes intracranial electrodes (subdural and depth) bipolar electrode pairs to monitor key epileptic network sites for the onset of seizure. When the beginning of a seizure is detected, a sequence of high frequency electric stimuli is delivered to one or more of the electrode pairs to disrupt the abnormal network activity. Thus, for both detection and treatment, it is important the electrodes are at sites of high epileptic network connectivity. Epileptic network connectivity of a cortical site can be quantified by the average coherence with other sites in the epileptic network. In this paper, MEG coherence imaging is used to generate whole brain images of epileptic network connectivity and study the relationship between seizure reduction and electrode placement.
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