MEG and Intracranial EEG Source Localization with Particularized Frequency in Tuberous Sclerosis Complex

Abstract

Event Abstract Back to Event MEG and Intracranial EEG Source Localization with Particularized Frequency in Tuberous Sclerosis Complex Hisako Fujiwara1*, Douglas Rose1, Ki Lee1, Francesco Mangano1, Nat Hemasilpin1 and David Franz1 1 University of Cincinnati, Cincinnati Children's Hospital Medical Center, United States Tuberous sclerosis complex (TSC) presents multifocally in both hemispheres and patients can have several types of medically intractable seizures. . Identification of the dominant focal seizure and the corresponding epileptogenic zone is crucial for surgical success. We compared TSC patients with interictal/ictal MEG discharges and ictal onset of intracranial EEG (ICEEG) source localization and evaluated both the distance to nearest tuber and distance to the ictal onset zone (IOZ). Sixteen patients with medically intractable epilepsy secondary to TSC underwent presurgical evaluation followed by resective surgery. We reviewed ictal semiology, scalp interictal/ictal EEG lateralization/localization, MRI lesions (presence of prominent tubers/calcification). We performed MEG interictal/ictal source localization with synthetic aperture magnetometry (SAM) for all patients, and single rotating current dipole (SRCD), standardized low resolution brain electromagnetic tomography (sLORETA) and multiple signal classification (MUSIC) for all patients. Five of 16 patients who had one area of limited corticectomy showed MEG source localization within 2 cm maximum distance from the tuber and the center of the IOZ according to visual inspection. In 7 patients who had multilobe corticectomy/lobectomy MEG sources were part of the resected areas. For only one patient with epileptic spasms, MEG failed to localize the epileptogenic zone. For two patients, MEG had technical difficulty localizing sources because of excessive diffuse beta activities. One patient who had a seizure during the MEG recording showed closer and better source localization in terms of the depth of source. MEG source localization with multiple algorithms was able to localize IOZ in patients who had both single and multiple epileptogenic zones. These methods may be helpful to reveal not only IOZ but also distributed epileptogenic zones in TSC. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG: Clinical applications Citation: Fujiwara H, Rose D, Lee K, Mangano F, Hemasilpin N and Franz D (2010). MEG and Intracranial EEG Source Localization with Particularized Frequency in Tuberous Sclerosis Complex. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00299 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Apr 2010; Published Online: 05 Apr 2010. * Correspondence: Hisako Fujiwara, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, United States, Hisako.Fujiwara@cchmc.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hisako Fujiwara Douglas Rose Ki Lee Francesco Mangano Nat Hemasilpin David Franz Google Hisako Fujiwara Douglas Rose Ki Lee Francesco Mangano Nat Hemasilpin David Franz Google Scholar Hisako Fujiwara Douglas Rose Ki Lee Francesco Mangano Nat Hemasilpin David Franz PubMed Hisako Fujiwara Douglas Rose Ki Lee Francesco Mangano Nat Hemasilpin David Franz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.