MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses.

Shan-Shan Tang,Lan Tan,Wei Zhang,Hui-Fu Wang,Chen-Chen Tan,Jin-Tai Yu,Zi-Xuan Wang,Teng Jiang,Meng-Shan Tan,Zhan-Jie Zheng,Ling-Li Kong,Lin Tan

doi:10.18632/oncotarget.9819

Abstract

The myocyte enhancer factor (MEF2) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C (MEF2C) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer's disease (LOAD) in Caucasians in a large meta-analysis of genome-wide association studies (GWAS). Here, we recruited unrelated 984 LOAD patients and 1348 healthy controls matched for gender and age to ascertain whether the rs190982 polymorphism is related to LOAD in Han Chinese. No difference in the genotype and allele distributions of the MEF2C rs190982 polymorphism was found between LOAD cases and healthy controls (genotype: P = 0.861; allele: P = 0.862), even after stratification for APOE ε4 allele as well as statistical adjustment for age, gender and APOE ε4 status. Furthermore, the meta-analysis in 4089 Chinese individuals did not detect the association of rs190982 within MEF2C with the risk for LOAD (OR = 1.03, 95%CI = 0.90-1.18). Overall, the current evidence did not support the relation between rs190982 polymorphism within MEF2C and the LOAD risk in Northern Han Chinese.

Highlights

Alzheimer’s disease (AD) is defined clinically by gradual decline in cognition and function as well as loss of memory and pathologically by extensive neuronal and synaptic loss, intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) peptides deposition [1, 2]
No significant difference was found in allele frequency between late-onset Alzheimer’s disease (LOAD) patients and controls (OR = 0.986, 95% confidence interval (CI) = 0.842-1.155, P = 0.862)
Myocyte enhancer factor 2 (MEF2) family is a member of the transcription factors, which is vital for linking external stimuli to protein production

Summary

Introduction

Alzheimer’s disease (AD) is defined clinically by gradual decline in cognition and function as well as loss of memory and pathologically by extensive neuronal and synaptic loss, intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) peptides deposition [1, 2]. Mutations in β-amyloid precursor protein (APP), presenilin 1 1) and presenilin 2 (PSEN 2) genes contribute to the uncommon early-onset form of the disease (onset < 65 years; EOAD) [4]. As to the more common late-onset AD (onset > 65 years; LOAD), only the APOE ε4 has been consistently identified to be a risk factor of the disease [5]. Some GWAS have identified 21 additional genetic susceptibility factors for LOAD including bridging integrator 1 (BIN1), inositol polyphosphate-5-phosphatase D (INPP5D), triggering receptor expressed on myeloid cell 2 (TREM2), NME8 (encoding NME/NM23 family www.impactjournals.com/oncotarget AD (n = 984).

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