Abstract
The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany. The topics followed-up the discussions of the previous workshops: possible differences in mitogenicity between natural insulin and genetically engineered insulin derivatives (insulin analogues), as shown by laboratory studies and epidemiologic studies alike; molecular studies on the links between metabolic and mitogenic effects of insulin, and of hyperinsulinaemia in particular; epidemiologic evidence of interferences between insulin and other hormones, particularly sex hormones, and obesity-associated cancer; the involvement of inflammatory cytokines produced by fat tissue in obesity-associated cancer; aspects of drug-design (binding drugs to albumin) and, last but not least, detection and investigation of circulating cancer cells.
Highlights
The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany
The sessions started with issues related to the mitogenicity of insulin analogues
* Correspondence: chantelau@gmx.de 1Formerly Heinrich-Heine-University, Düsseldorf, Germany Full list of author information is available at the end of the article presented her recent investigations of insulin analogues in breast cancer cells showing an increased mitogenicity of Lantus® in cells highly expressing IGF-1 receptors
Summary
The 3rd International Workshop on Insulin & Cancer was held on October 30-31, 2010 at the German Cancer Research Centre in Heidelberg/Germany. The sessions started with issues related to the mitogenicity of insulin analogues. With respect to the recent commission by the EMEA “to further investigate the possible increased risk of cancer associated with the use of insulin glargine...” [2], the safety profile of insulin glargine (Lantus®) was of particular interest.
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