Abstract

BackgroundInformation about the achievement of glycemic targets in patients with type 2 diabetes according to different individualization strategies is scarce. Our aim was to analyze the allocation of type 2 diabetic patients into individualized glycemic targets according to different strategies of individualization and to assess the degree of achievement of adequate control.MethodsCross-sectional analysis on 5382 type 2 diabetic patients in primary care setting in Spain between 2011 and 2012. Targets of HbA1c were assigned based on different strategies of individualization of glycemic targets: 1) the ADA/EASD consensus 2) The Spanish Diabetes Society (SED) consensus 3) a strategy that accounts for the risk of hypoglycemia (HYPO) considering the presence of a hypoglycemia during the last year and type of hypoglycemic treatment. Concordance between the different strategies was analyzed.ResultsA total of 15.9, 17.1 and 67 % applied to ADA/EASD recommendation of HbA1c target of <6.5, < 7 and <8 % (48, 53 and 64 mmol/mol), and 31.9 and 67.4 % applied to the SED glycemic target of <6.5 and <7.5 % (<48 and 58 mmol/mol). Using the HYPO strategy, 53.5 % had a recommended HbA1c target <7 % (53 mmol/mol). There is a 94 % concordance between the ADA/EASD and SED strategies, and a concordance of 41–42 % between these strategies and HYPO strategy. Using the three different strategies, the overall proportion of patients achieving glycemic targets was 56–68 %.ConclusionsIndividualization of glycemic targets increases the number of patients who are considered adequately controlled. The proposed HYPO strategy identifies a similar proportion of patients that achieve adequate glycemic control than ADA/EASD or SED strategies, but its concordance with these strategies in terms of patient classification is bad.

Highlights

  • Information about the achievement of glycemic targets in patients with type 2 diabetes according to different individualization strategies is scarce

  • Individualization of glycemic targets based on ADA/EASD consensus (n = 5267) Using the ADA/EASD consensus and including information regarding patients’ age, duration of diabetes and the presence of diabetic complications, a target HbA1c of < 6.5 % (48 mmol/mol) applied to 15.9 % of the study population, while the conventional target of < 7 % (53 mmol/mol) applied to 17.1 %

  • The individualization of glycemic targets using different recommended strategies, such as the ADA/EASD strategy used by Laiteerapong et al [2, 6] or the SED consensus strategies [3], reveals that 56–68 % of Spanish diabetic patients receiving pharmacological treatment are under adequate metabolic control

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Summary

Introduction

Information about the achievement of glycemic targets in patients with type 2 diabetes according to different individualization strategies is scarce. Our aim was to analyze the allocation of type 2 diabetic patients into individualized glycemic targets according to different strategies of individualization and to assess the degree of achievement of adequate control. Despite the widespread acceptance of individualized glycemic control in patients with type 2 diabetes, information on the number of patients reaching these new recommended targets in different populations is scarce [6,7,8]. In the analysis by Laiteerapong et al [6], individualization of glycemic targets was performed taking into account the patient’s age, duration of diabetes, diabetes complications and significant comorbidities, but not the risk and the past history of hypoglycemia. History of past hypoglycemia and insulin treatment are known and important predictors of a future hypoglycemic event [9,10,11], and, as stated in different recommendations, are important aspects to consider when assigning a patient to a certain HbA1c target

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