Meet the Editorial Board:

Abstract

Pr Christian Neri, Ph.D, Research Director at INSERM and Associate Professor at the University of Montreal has a long-standing experience in the field of genome science and degenerative disease research. The Neri lab is part of the Institute of Biology Paris-Seine (IBPS) on the UPMC campus of Jussieu in Paris and studies of how neurons may use longevity-promoting systems to compensate for the cellular stress associated with neuronal dysfunction in neurodegenerative diseases such as Hun-tington’s disease (HD). The Neri lab used C. elegans models to discover that key longevity modulators such as sirtuin SIRT1 and transcription factor FOXO3 help neurons maintain function and resist neurodegenerative disease, has extended this notion to other degenerative diseases. In 2014, the Neri lab discovered that the capacity of neurons to properly use FOXO3 factors and cope with chronic cellular stress in HD is disrupted by abnormal neurodevelopmental signaling activity from the earliest phases of the disease process, emphasizing the importance of understanding the regulation of stress response gene regulatory networks in diseased neurons and value of sustaining neuronal resistance to fight neurodegenerative disease. The current re-search interest of the Neri lab is on the genetic/epigenetic regulation and clinical potential of neuronal-stress response networks in HD and age-related diseases. Pr. Neri serves as Lead Facilitator of the European HD Network (EHDN), Chairman of the Sci-entific Council of Association Huntington France (AHF) and Director of Science of the AP-HP University Hospital Department ‘Fight Aging and Stress’, promoting international research efforts on stress resilience and brain longevity in neurodegenerative disease and ageing.