Abstract
Medulloblastoma or not? Crucial role in tumorigenesis of the timing of migration of cerebellar granule precursor cells, regulated by Nos2 and Tis21
Highlights
Medulloblastoma is a very aggressive tumor of the cerebellum and one of the most common malignant pediatric brain tumors
Two recent studies (Farioli-Vecchioli et al, 2012a; Haag et al, 2012) have highlighted that the localization of preneoplastic GCPs during cerebellar development plays a crucial role for their malignant progression
Ablation of Tis21 does not influence the proliferation of GCPs [ suggesting that other genes of the same family expressed in the cerebellum, such as Btg1 (Farioli-Vecchioli et al, 2012b), may vicariate the known antiproliferative action of Tis21]
Summary
Medulloblastoma is a very aggressive tumor of the cerebellum and one of the most common malignant pediatric brain tumors. These studies show that ablation of Nos2 (nitric oxide synthase) or of Tis21 ( known as Btg2 or PC3) leads to impairment of the migration of GCPs from the surface of the cerebellum toward the internal layers.
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