Medulloblastoma of Posterior Cranial Fossa in Children:a Report of 42 Cases

Abstract

Objective:To improve the diagnosis and therapy of medulloblastoma of posterior cranial fossa in children.Clinical data:Forty-two cases(male 28,female 14)aging from 1.5 to 12 years(mean 7.3 yrs)were admitted.The lesions were in vermis(36),and cerebellar hemisphere (6).All cases presented symptoms and signs with increased intracranial pressure,and 31 had signs of cerebellar functional deficiency.CT scan showed marked obstructive hydrocephalus in 39 cases.Three died of postoperative respiratory and circulatory failure.Thirty-nine survivors received craniospinal radiotherapy plus chemotherapy have recoverd well.Conclusions:Surgical resection with postoperative low-dose craniospinsl radiotherapy and chemotherapy is a better procedure for medulloblastoma of posterior cranial fossa in children. Key words: Medulloblastoma; Decompression; Radiotherapy