Medium-term repeatability for airwave oscillometry in patients with severe asthma taking benralizumab.

Abstract

The effort-independent tidal breathing test used by oscillometry presents a viable alternative for following up patients whose condition is stable while they are receiving biologic therapy. We aimed to determine intrasession and intersession repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab. In all, 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as partof a clinical trial (EudraCT identification number 2019-003763-22). Paired AOS and spirometry values were obtained at 3 separate visits (baseline and days 28 and 56) with no change in asthma therapy. Intrasession agreement between repeated measurements for AOS and spirometry was excellent (intraclass correlation coefficient≥ 0.90) at all 3 visits. Intersession agreement was also excellent (intraclass correlation coefficient≥ 0.80). In this study we report medium-term intrasession and intersession repeatability values for airwave oscillometry and spirometry in a cohort of severely asthmatic patients receiving benralizumab therapy. Oscillometry can be used to follow up patients with asthma who are taking biologics.