Abstract
Medium Molecular Weight Chitosan as a Carrier for Delivery of Lincomycin Hydrochloride from Intra-pocket Dental Film: Design, Development, in vitro and ex vivo Characterization
Highlights
The two major kinds of inflammatory diseases affecting the periodontium are periodontitis and gingivitis
The purpose of investigation is to find out the potential of Medium Molecular Weight Chitosan (MMWCH) loaded with Lincomycin Hydrochloride (LNC) having pKa 7.6 and log p value 0.20 for treatment of periodontitis and gingivitis, prepared by using solvent casting technology in form of intra pocket dental film
Following are the criteria for designing the dental films such as they have to be small, since the average pocket depth is between 610mm and it cannot be exposed beyond the gingival margin when inserted into the periodontal pocket, it should not cause any interference with the normal oral hygiene, the active ingredient in the prepared film should display therapeutic effectiveness at a slow rate so as to obtain a sustained effect and antimicrobial drug should be highly specific against the various bacteria present in the pocket (Jeffcoat et al, 1998)
Summary
The two major kinds of inflammatory diseases affecting the periodontium are periodontitis and gingivitis. Gingivitis occurs due to inflammation of the gingival that does not lead to the clinical attachment loss by affecting the Ganjoo et al / Journal of Applied Pharmaceutical Science 6 (10); 2016: 008-019. This periodontal pocket provides ideal conditions for proliferation of various micro-organisms, especially gram negative, facultative anaerobic species. The dimensions and shape of films can be controlled so as to correspond to the dimensions of the pocket where the film is to be inserted It can be quickly inserted into the sac with minimal pain to the patient. Following are the criteria for designing the dental films such as they have to be small, since the average pocket depth is between 610mm and it cannot be exposed beyond the gingival margin when inserted into the periodontal pocket, it should not cause any interference with the normal oral hygiene, the active ingredient in the prepared film should display therapeutic effectiveness at a slow rate so as to obtain a sustained effect and antimicrobial drug should be highly specific against the various bacteria present in the pocket (Jeffcoat et al, 1998)
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