Abstract
Background: UVA1 radiation seems to be effective in morphea. CD34+ dendritic cells are significantly decreased in lesional skin of morphea patients. Objective: We evaluated the therapeutic effectiveness of medium-dose UVA1 phototherapy in localized scleroderma and its effect in the number of dermal CD34+ dendritic cells in skin biopsy specimens of these patients. Method: Patients were irradiated with UVA1 (30 J/cm2) 30 times. Dermal CD34+ dendritic cells were counted before and after therapy. Results: There was clinical improvement after UVA1 irradiation. Dermal CD3 4+ dendritic cells significantly increased after UVA1 irradiation. Conclusion: Medium-dose UVA1 therapy is effective in the treatment of localized morphea. Effectiveness is associated with an increase in the number of CD34+ dendritic cells in the dermis. (J Am Acad Dermatol 2001;45:697-9.)
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