Abstract
BackgroundMediterranean diet (MediDiet) had been reported to be beneficial to human health. However the relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. This study was aimed to explore the correlation between MediDiet pattern of infertile women and their clinical outcomes of IVF cycles.MethodsAn observational prospective cohort study was conducted in the reproductive center from September 2016 to December 2017. Seven hundred infertile women about to undergo IVF treatment were asked to conduct a questionnaire survey. Patients were assigned to higher MediDiet adherence group or lower MediDiet adherence group according to their Mediterranean diet scores. Laboratory parameters and clinical outcomes were compared and those were different between groups were further analyzed for their relationship with MediDiet adherence.ResultsA total of 590 women were finally included in the study. According to MediDiet scores, 228 participants were categorized as higher MediDiet adherence group and 362 others as lower MediDiet adherence group. No significant differences were found in baseline characteristics between groups. Higher MediDiet adherence group showed larger number of embryos available (8.40 ± 5.26 vs 7.40 ± 4.71, P = 0.028). Clinical pregnancy rate and implantation rate were similar between the two groups. In further correlation tests and multivariate linear regression analysis, number of fertilized oocytes and embryo yield were positively correlated to MediDiet adherence of participants.ConclusionInfertile women with greater adherence to Mediterranean diet pattern were likely to obtain more embryos available in IVF cycle.
Highlights
Mediterranean diet (MediDiet) had been reported to be beneficial to human health
A total of 700 infertile women were provided with questionnaires and 699 of them finished the food frequency questionnaire (FFQ), while one patient did not fulfill it
Among the 678 patients left, 590 used Gonadotropin-releasing hormone (GnRH) agonist long protocol or GnRH antagonist protocol for controlled ovarian hyperstimulation (COH) and they were included for this study
Summary
The relationship between diet pattern and outcomes of in vitro fertilization (IVF) treatment was scarcely researched. This study was aimed to explore the correlation between MediDiet pattern of infertile women and their clinical outcomes of IVF cycles. As an important factor to female health, the role of dietary status in IVF treatment has been rarely studied. It has been reported that light dairy products [3], animal protein [4], carbohydrates [5] and trans unsaturated fats [6] are correlated with ovulatory infertility. In a study from the USA [8], women with highest adherence to “fertility diet” (higher consumption of monounsaturated rather than trans fats, vegetable rather than animal protein sources, low carbohydrates, high fat dairy, multivitamins, and iron from plants and supplements) had a lower risk of infertility compared to women with the lowest adherence. Twigt et al [9] found that increasing adherence to Dutch dietary recommendations in 199
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