Abstract
To the Editor High levels of chronic stress are associated with an increased incidence of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) (1, 2) and negatively impact the hippocampus, a key AD brain region. Mindfulness Based Stress Reduction (MBSR), a standardized mindfulness meditation/yoga intervention, may decrease stress/cortisol, improve well-being, and increase hippocampal gray matter density in healthy adults. (3, 4) Studies also demonstrate that meditation selectively activates the hippocampus,(5) and experienced meditators have larger hippocampal volumes and gray matter compared to controls. (6) Within this context, our objectives were to: 1) test the safety/feasibility of MBSR in adults with MCI; 2) explore the effects of MBSR on cognition and well-being through standardized instruments, neuropsychological evaluations, and interviews.
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