Abstract
The recent publication of the Perindopril Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) study showed that perindopril significantly reduced the composite risk of death, hospitalisation for heart failure, and cardiac remodeling in an elderly population with preserved left ventricular (LV) function, following an acute myocardial infarction. In light of this trial, this edition of the Medifile reviews the process of cardiac remodelling post infarction, with specific focus on the role of the Renin-Angiotensin-Aldosterone System (RAAS). The results and clinical significance of PREAMI are then reviewed and discussed. More....
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