Abstract
Alzheimer's disease is the most common cause of dementia, accounting for an estimated 60% to 80% of cases. The treatment of Alzheimer's disease remains challenging. Many medicinal plants possessed beneficial therapeutic effect inAlzheimer’s disease and memory deficits, by their anti-inflammatory, antioxidant, neuroprotective, NF-κB inhibition, phosphodiesterase inhibition, anti-amyloidogenic, and anticholinesterase activities. In the current article, the medicinal plants with beneficial effects in Alzheimer’s disease and memory deficits were discussed. This article considers not only the therapeutic effect of medicinal plants in AD and memory deficits, but also discussed the mechanisms of their beneficial effects.
Highlights
Alzheimer’s disease (AD) is a progressive neurological disease of the brain, it is the most common form of dementia and affects an estimated 10 million people worldwide
Total time spent in dark room (DS), which opposed the memory retention ability, in amnestic control (AC) was significantly greater than amnestic treated (AT) group at 1 and 2 hours after full training, while there was no significant difference in this parameter between amnestic prophylaxis (AP) and AT [74]
The results revealed that Gossypium herbaceam (GHE) exhibited certain activities against AChE and is an efficient free radical scavenger, which may be helpful in preventing or alleviating patients suffering from Alzheimer's disease [119]
Summary
Alzheimer’s disease (AD) is a progressive neurological disease of the brain, it is the most common form of dementia and affects an estimated 10 million people worldwide. Memory impairment is the hallmark symptom of Alzheimer’s disease. Dementia is characterized by progressive deterioration in cognitive domains, including memory, language, executive and visuospatial function, personality and behavior. Many medicinal plants possessed beneficial therapeutic effect in Alzheimer’s disease and memory deficits [4,5,6], by their anti-inflammatory, antioxidant, neuroprotective, NF-κB inhibition, phosphodiesterase inhibition, anti-amyloidogenic, and anticholinesterase activities [7,8,9,10,11]. The beneficial effects of medicinal plants in the treatment of memory deficitsand Alzheimer’s disease were discussed. This article considers the therapeutic effect of medicinal plants in AD, and in the understanding the mechanisms of their beneficial effects. 2. Medicinal plants with beneficial therapeutic effects in Alzheimer’s disease and memory deficits
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