Abstract
Hypertrophic scar is a complication of wound healing and has a high recurrence rate which can lead to significant abnormity in aesthetics and functions. To date, no ideal treatment method has been established. Meanwhile, the underlying mechanism of hypertrophic scarring has not been clearly defined. Although a large amount of scientific research has been reported on the use of medicinal plants as a natural source of treatment for hypertrophic scarring, it is currently scattered across a wide range of publications. Therefore, a systematic summary and knowledge for future prospects are necessary to facilitate further medicinal plant research for their potential use as antihypertrophic scar agents. A bibliographic investigation was accomplished by focusing on medicinal plants which have been scientifically tested in vitro and/or in vivo and proved as potential agents for the treatment of hypertrophic scars. Although the chemical components and mechanisms of action of medicinal plants with antihypertrophic scarring potential have been investigated, many others remain unknown. More investigations and clinical trials are necessary to make use of these medical plants reasonably and phytotherapy is a promising therapeutic approach against hypertrophic scars.
Highlights
Scar formation strongly depends on the presence of contraction during healing and the nature of the scar is the uneven look of the healed tissue resulting from disfigured tissue deformation and overaligned collagen fibers [1]
In line with the latest findings responsible for the increased recognition of medicinal plants as potential therapeutic and/or preventative agents, the aim of the present review is to focus on recent experimental findings and clinical trials of medicinal plants and other preparations with similar actions that could account for beneficial effects on hypertrophic scars in patients
We gathered publications on medicinal plants with antihypertrophic scar activity and addressed the question whether the treatment of scars with medicinal plants is effective in humans
Summary
Scar formation strongly depends on the presence of contraction during healing and the nature of the scar is the uneven look of the healed tissue resulting from disfigured tissue deformation and overaligned collagen fibers [1]. Collagen in hypertrophic scars is found to be in a disorganized, whorl-like arrangement rather than in the normal parallel orientation manner. Hypertrophic scars are indurate, elevated, poorly extensible, and characterized by hypervascularity, thereby providing their erythematous appearances [2]. HS can cause significant abnormality in aesthetic and functional symptoms and to date no recognized treatment has been established. It commonly occurs after surgical incision, thermal injury, and traumatic injuries to the dermis with a subsequent abnormal healing response [3]. It is often associated with contractures that can lead to considerably reduced functional performance in patients
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