Abstract

This study was performed to examine the effects of medicinal plant extracts of corn silk (Stigma maydis), parsley leaf (Petroselini folium), and bearberry leaf (Uvae ursi folium) on antioxidant status of the brain of experimental animals (mice) under the physiological conditions. Biological properties of these plants are insufficiently investigated and the aim was to explore their possible antioxidant effects that can alleviate oxidative damage of the brain tissue. Corn silk extract showed positive effect on activities of antioxidant enzymes in mice brain tissue. Parsley extract induced the increase in glutathione content and decrease of lipid peroxidation. Bearberry leaf extract induced catalase activity and decrease of hydroxyl radical content, while malonyldialdehide accumulation was maintained at the control level. Results obtained in this study support the use of corn silk, parsley and bearberry leaves as natural antioxidant sources in the prevention and treatment of brain tissue damages and different diseases caused by oxidative stress.

Highlights

  • Oxidative stress is one of the biggest threats to brain cells because of their large oxygen consumption.[1]

  • superoxide dismutase (SOD) isoenzymes play an important role in cerebral ischemia, in reperfusion injury when brain cells are resupplied with oxygen that leads to overproduction of reactive oxygen species (ROS) and lipid peroxidation (LP) process

  • Bolic stress, it is important that all scavenging mechanisms are active[27], which was achieved by corn silk extract in our experiment

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Summary

Introduction

Oxidative stress is one of the biggest threats to brain cells because of their large oxygen consumption.[1]. The brain, like the other organs in aerobic organisms, has potent defenses against superoxide, including enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (GPx), glutathione peroxidase (GSH-Px) and reduced glutathione as nonenzymatic antioxidant (GSH).[6]

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