Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review.

Atefehalsadat Seyedan,Mohammed Abdullah Alshawsh,Zahurin Mohamed,Mustafa Ahmed Alshagga,Sanaz Koosha

doi:10.1155/2015/973143

Abstract

Obesity is recognized as a major life style disorder especially in developing countries and it is prevailing at an alarming speed in new world countries due to fast food intake, industrialization, and reduction of physical activity. Furthermore, it is associated with a vast number of chronic diseases and disabilities. To date, relatively effective drugs, from either natural or synthetic sources, are generally associated with serious side effects, often leading to cessation of clinical trials or even withdrawal from the market. In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect. Pancreatic lipase inhibitory activity has been extensively used for the determination of potential efficacy of natural products as antiobesity agents. In attempts to identify natural products for overcoming obesity, more researches have been focused on the identification of newer pancreatic lipase inhibitors with less unpleasant adverse effects. In this review, we consider the potential role of plants that have been investigated for their pancreatic lipase inhibitory activity.

Highlights

Obesity, which has been termed as the “New World Syndrome,” is considered a global problem by the World Health Organization (WHO) and is associated with a vast number of chronic diseases and disabilities like dyslipidemia, fatty liver disease, osteoarthritis, hypertension, obstructive sleep apnea, gallstones, type 2 diabetes, reproductive and gastrointestinal cancers, coronary artery disease, heart failure, and stroke [1, 2]
As drugs have failed to give desirable long-term results, it is significant to say that, in the last 10–20 years, a pervasive inspection began in order to clarify the most helpful source of new antiobesity compounds of natural products and to take over the present relative drug of doubtful effectiveness
In the last few years, interest in herbal medicines has increased and about 500 various plant species are used as key ingredients, while most are still being collected from the wild [78]

Summary

Introduction

Obesity, which has been termed as the “New World Syndrome,” is considered a global problem by the World Health Organization (WHO) and is associated with a vast number of chronic diseases and disabilities like dyslipidemia, fatty liver disease, osteoarthritis, hypertension, obstructive sleep apnea, gallstones, type 2 diabetes, reproductive and gastrointestinal cancers, coronary artery disease, heart failure, and stroke [1, 2]. In 2008, the use of rimonabant was suspended by EMA due to an increased risk of psychiatric side effects such as anxiety, suicidal ideation, sleep disorders, and depression. It is an appetite suppressant and was available in 56 countries from 2006 but it was never approved by the Food and Drug Administration (FDA) [13]. Only orlistat (Xenical), a drug which is considered to be acting through inhibition of pancreatic lipase enzyme, a key enzyme for the digestion of dietary triglycerides, has been approved by FDA and is available for longterm treatment of obesity. We consider the potential role of plants as antiobesity agents through investigation of their pancreatic lipase inhibition property

Appetite Regulation

Inhibitors of Adipogenesis

Inhibition of Fat Absorption

Pancreatic Lipase Inhibitors from Natural Products

Findings

Summary