Abstract
AbstractFollowing the discovery of salicylates and its conversion to aspirin, natural products research has provided many promising leads for further modification as anti‐inflammatory and analgesic agents. Recent studies have focused on biosynthesis inhibitors of eicosanoids and receptor antagonists of the platelet activating factor, including a new class of dual functional inhibitors derived from neolignans. The highly potent analgesic alkaloid epibatidine from the frog skin has been synthesized and recharacterized as a very strong acetylcholine nicotinic receptor agonist. Some novel epibatidine analogs have shown promise as potential CNS drugs and research probes for clarifying the anti‐addictive property of the African alkaloid ibogaine.
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