Medications adherence in patients with osteoporosis after vertebroplasty or kyphoplasty at Hanoi Medical University Hospital

Abstract

Poor adherence to medication therapy is currently one of the most critical obstacles facing osteoporosis care and it is one of the main barriers for optimal therapeutic osteoporosis management, especially after surgical intervention. This paper presents medication adherence and explores factors associated with medications non-adherence in patients with osteoporosis after vertebroplasty or kyphoplasty. This is a retrospective case series included osteoporosis patients underwent vertebroplasty or kyphoplasty at Hanoi Medical University Hospital in 2019. Medication adherence was assessed using the validated Osteoporosis specific Morisky Medication Adherence Scale. A total of 42 patients participated in the study. Level of osteoporosis medication adherence decreased gradually with time of using medication: high adherence level after 1 month with OS-MMAS score was 8. Mean score of medium and low adherence after 3 months and 6 months were 6.64 ± 1.19 and 4.64 ± 2.18, respectively . 57.14% of participants had low adherence (6 months). 73.81% patients forgot to take medication. The associated factors of medication adherence are residence area, occupation, education level, number of medication used, frequency of osteoporosis medication, failure to take medication and side effects. The current study reveals a low level of medication adherence and sheds the light on different causes of medication non-adherence among patients with osteoporosis after vertebroplasty or kyphoplasty. Identifying barriers for medication non-adherence is an important initial step for developing effective clinical pharmacy interventions for patients with osteoporosis.