Medicament role in the etiology of allergic contact skin eruptions

Abstract

The medicament skin eruptions are frequently observed in medical practice. They occur in various clinical types, defined into four groups: urticaria, maculo-papular eruptions, vasculitis and a non-homogeneous group - others. The allergic contact dermatitis and contact urticaria increase the range of the medicament skinre ac tions.Theyarepro vokedbylo callyap pliedan ti bi ot ics,an es thet icsandnon-steroid anti-inflammatory agents. The accurate clarification of the etiopathogenesis of the allergic contact eruptions provides adequate therapy and suitable prophylactic strategy for each case. The research covers 112 patients with al ler gic con tact der ma ti tis and con tact ur ti caria. The eti ol ogy has been clar i fied through anamnestic data, clinical study, skin tests /skin scraping, epicutaneous/. Of all the patients included in the research, 87 patients with al ler gic con tact der ma ti tis and 12 with con tact ur ti caria were eti o log i cally clar i fied, whereas 13 patients remained with unclear etiology. The most frequent etiological causes for the allergic contact medicament skin eruptions proved to be local antibiotics /37.5%/, followed by localnon-steroid anti-inflammatory agents /30.7%/, local anesthetics /26.9%/ and local corticosteroids /2.8%/.