Abstract
Sodium thiosulfate (STS) is an industrial chemical which also has a long medical history. It was originally used as an intravenous medication for metal poisoning. It has since been approved for the treatment of certain rare medical conditions. These include cyanide poisoning, calciphylaxis, and cisplatin toxicity. In vitro assays have demonstrated that it is an anti-inflammatory and neuroprotective agent. It therefore has potential for treating neurodegenerative diseases such as Alzheimer disease and Parkinson disease. NaSH has similar properties and is somewhat more powerful than STS in these in vitro assays. However STS has already been approved as an orally available treatment. STS may therefore be a readily available candidate for treating neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Highlights
Sodium thiosulfate (Na2S2O3, STS) is an industrial compound which has a long history of medical use
One of the early medical uses of STS was in the successful treatment of arsenic, lead, mercury and bismuth poisoning[1]
The ineffectiveness of oral administration suggests that relatively high amounts are required to treat overdoses of poisonous elements
Summary
Sodium thiosulfate (Na2S2O3, STS) is an industrial compound which has a long history of medical use Since it is employed as a food preservative, the general population is widely exposed to this non-toxic compound. Shiels[3] described the use of STS to treat chronic lead poisoning at the Mount Ina mine in Australia. There were dozens of lead poisoning cases being diagnosed each year Many such cases were successfully treated with intravenous injections of STS. The condition is typically fatal but a 50% survival rate was achieved with administration of intravenous fluids and STS. In these conditions, oral administration was ineffective. The ineffectiveness of oral administration suggests that relatively high amounts are required to treat overdoses of poisonous elements
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