Abstract
ade noma of the pituitary gland, causes morbidity and mortality in affected patients by both local and peripheral physical changes (1-7). First, GR-secreting ade nomas, like other tumors of the pituitary, cause compression of surrounding neural and bony structures, among which are the normal pituitary tissues, the sphenoid and cavernous sinuses, optic nerves, and third ventricle. Second, the excess secretion of GR in acromegaly can lead to changes in the peripheral tissues, which result in gross disfigurement of the face, hands, and other parts of the body; crippling arthritis; carpal tunnel syndromes; heart disease; hyper tension; lung disease; a number of dermal changes; and carbohydrate and lipid abnormalities. Obviously, patients with acromegaly require therapeutic
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