Abstract
There are no randomized controlled trials that demonstrate that any medical therapy reduces adverse events in patients with undifferentiated chest pain evaluated in chest pain units (CPUs). Many of the millions of patients that present to the emergency departments (EDs) in the United States with chest pain are managed in CPUs, but the vast majority of these patients do not suffer an acute coronary syndrome (ACS). Studies have shown that only ˜2% of patients evaluated in CPUs are diagnosed with myocardial infarction (MI) (Newby et al. Am J Cardiol 85(7):801–5, 2000; Farkouh et al. N Eng J Med 339(26):1882–8, 1998). This chapter will address the role of aspirin (ASA), nitrates, heparin, and beta blockers in the patients with undifferentiated chest pain in the CPU.
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