Abstract
DesignRandomised, placebo-controlled trial. ParticipantsWomen included in this trial were aged between 19 and 41 years and were recruited from Emory Clinic and Crawford Long Hospital, affiliated to Emory University School of Medicine in Atlanta, Georgia. The inclusion criteria included women with pelvic pain and a history of endometriosis and/or infertility. A total of 59 women were included in the trial. InterventionThe total of 59 women were randomised into one of the two research arms of group A (n = 46) given vitamin E and vitamin C combinations or group B (n = 13) placebo pills. The interventions involved vitamin E 1200 IU (3 capsules of 400 mg each) and vitamin C 1000 mg (2 tablets of 500 mg each) daily for eight weeks prior to surgery. ComparatorA placebo arm of 13 women with endometriosis and/or infertility. SettingsEmory University School of Medicine, Atlanta, Georgia, United States of America. ConclusionThis trial identified that daily antioxidant supplementation with vitamin E and vitamin C for a period of eight weeks showed significance in reducing peritoneal inflammatory markers, which may be responsible for the development of pain in endometriosis. The trial also demonstrated that combination supplementation of vitamin E and vitamin C lowered chronic pelvic pain in women with endometriosis. The findings indicate that supplementation with nutritional medicines that interact with inflammatory processes may be of benefit to women with endometriosis and may be used in conjunction with other treatment regimens from their health care provider.
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