Medical support of rehabilitation of stroke patients: the role of GABA-ergic drugs

Abstract

Introduction. The relevance of neuroprotective therapy in patients with cerebral stroke (CS) is due to its high prevalence, as well as the need for the maximum possible restoration of damaged structures and functions of the central nervous system (CNS).Аim. Тo evaluate the clinical efficacy and nicotinoyl gamma-aminobutyric acid tolerance in the complex rehabilitation of patients in the late recovery and chronic periods of ischemic stroke (IS) in outpatient stage.Materials and methods. 110 patients in the late recovery period (LRP) and the residual period of IS, 57 women and 43 men, average age 58.0 ± 9.74 years, were observed. The duration of the stroke was on average 214 ± 28 days in PVP-patients and 428 ± 47 days for the residual period. All patients included in the study received a standard medical rehabilitation program. Two main groups included 30 patients in LRP and the residual period of IS, who treated with nicotinoyl gammaaminobutyric. Two control groups included 30 patients in LRP and 20 patients in the residual period of IS, who recievedonly the standard medical rehabilitation program.Results. The complex of rehabilitation with the inclusion of nicotinoyl gamma-aminobutyric acid (picamilon) significantly improved the indicators of neurodynamic (p < 0.05) and regulatory functions (p < 0.05) in the main subgroups on the MoCA scale, emotional status (p > 0.05 on the Beck scale), general well-being, activity, mood (WAM scale) and basic functional activity (the average Bartel index at the end of the study was 82.6 ± 3.5 in the main groups, p < 0.05). The clinical effect was observed after a month of the therapy and persisted until the end of the study.Conclusion. The inclusion of neuroprotective therapy in the complex rehabilitation leads to earlier neuropsychological and social adaptation of the patient, regression of fatigue, which is probably associated with an increase in neuroplastic and regulatory brain processes.