Medical Ozone: The Pharmacological Mechanisms Accounting for its Effectiveness against COVID-19/SARS-COV-2

Abstract

Introduction: Medical ozone has been used with safety and efficacy in different diseases of oxidative etiology, for the most part involving autoimmune diseases. Methods: An analysis of the pharmacological mechanism of action of ozone was carried out to explain its clinical effectiveness and its positive response in clinical patients to COVID-19. This was done in the context of the different therapeutic targets that have been demonstrated for ozone in other diseases (autoimmune and hypoxia status). Results: Based on the intestine/lung functional axis, the necessity of rectal insufflation as route of application with the aim of attaining improved results using medical ozone against COVID 19 is demonstrated. It was possible to identify at least nine adverse events/molecules which were targets of regulation through medical ozone in other diseases, including innate immune response, nuclear transcription factor NF-kB, “cytokine storm”, inflammation, severe acute respiratory syndrome and coagulopathy. Some of them lead to multi organ failure. Finally, a brief analysis is undertaken to show the regulatory effects of ozone versus the comorbidities contributing to virus lethality, including hyperglycemia and its vascular complications. Conclusions: Medical ozone is effective against COVID-19/SARS-CoV-2: due to the multiple targets it is able to regulate and thereby achieve a positive patient response.