Abstract
<h3>Daughters' cancers linked to mothers' use of estrogen</h3> Daughters of women who took stilbestrol during pregnancy should be carefully examined for adenocarcinoma of the vagina when they reach menarche. Although the incidence of these tumors in girls who were exposed to nonsteroidal synthetic estrogens in utero is probably very small, Harvard Medical School investigators believe that the association does exist and that it is the "first demonstration in humans of transplacental chemical carcinogenesis." Since reporting eight such cases one year ago, "more than 70 cases of vaginal and cervical adenocarcinomas in young women have been brought to our attention." In the vast majority of cases with a complete maternal medical history, reports Arthur L. Herbst, MD, there is a history of intrauterine exposure to stilbestrol, dinestrol, or hexestrol. Because complete medical records are not always available, Dr. Herbst advises: "Any young girl with excess vaginal bleeding and staining should
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