Abstract

Abstract Ethical choice and behavior in health care practice and research require an understanding of uncertainty and the contribution that can be made by statistical methods. Various criteria for judging what is “best” are discussed in relation to routine medical practice, the perception of “normality”, screening for disease, epidemiological research, and the communication of uncertainty. Attention is given to the ethics of reproducible research, medical research in developing countries, informed and uninformed consent, and cluster randomized trials. Guidelines provided by various national and international organizations are described.

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