Abstract

Numerous medical disorders may present with manic symptomatology. Conversely, general medical illness may also co-occur independently in patients with bipolar disorder. The purpose of this article is to summarize our current understanding of the co-occurrence of mania and medical illness. Neurological disorders, metabolic disturbances, prescription and illicit drug use, infectious diseases, and traumatic brain injuries have all been associated with mania. Additionally, temporal lobe epilepsy and migraine headaches have been found to be fairly common in patients with bipolar disorder. Further research is needed to assess the impact of these comorbid diagnoses on treatment response and prognosis in patients with co-occurring mania and primary medical disorders.

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