Abstract

Weight loss surgery is considered to be the most efficacious treatment for individuals with clinically severe class III obesity (BMI ≥ 40 kg/m2) or with moderate class II obesity (BMI ≥ 35–39.9 kg/m2) when accompanied by an obesity-related comorbidity. Significant improvement in multiple obesity-related comorbid conditions has been reported postoperatively, including type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, obstructive sleep apnea (OSA), and quality of life. However, long-term durability of weight loss and improvement in comorbid conditions are less certain, and weight regain has been observed. Although the causative factors of weight regain have not been well characterized, clinicians are being asked to evaluate an increasing number of patients postoperatively. This chapter will review the current information regarding weight gain following bariatric surgery and the factors associated with weight regain and present a proposed evaluation and treatment algorithm.

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