Medical Approach for Weight Loss in Nonalcoholic Fatty Liver Disease

Abstract

Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions due to obesity in the modern world. Although treatments are in development, weight loss remains the most definitive and impactful approach to treating this disease and with it the other multisystemic complications of obesity. In this review, we summarize the current medical therapies for weight loss in NAFLD, including patient evaluation, counseling, and incorporation of medications for obesity. Despite need for weight loss as treatment for NAFLD, few achieve successful weight loss. Weight loss medications lead to weight loss of 5 to 10%, the amount expected to improve NAFLD steatosis and fibrosis. Ultimately, a multimodal approach is necessary to achieve successful weight loss. Medical management for weight loss in NAFLD requires fibrosis staging and developing a patient-centered approach to assessment of patient weight and behavioral change goals.