Medical Application of Hydrogen in Hematological Diseases.

Liren Qian,Ciprian Tomuleasa,Sergiu Pasca,Jian Cen,Zhengcheng Wu

doi:10.1155/2019/3917393

Abstract

Hydrogen gas has been reported to have medical efficacy since the 1880s. Still, medical researchers did not pay much attention to hydrogen gas until the 20th century. Recent research, both basic and clinical, has proven that hydrogen is an important physiological regulatory factor with antioxidative, anti-inflammatory, and antiapoptotic effects. In the past two decades, more than 1000 papers have been published on the topic, including organ ischemia-reperfusion injury, radiation injury, diabetes, atherosclerosis, hypertension, or cancer. We have previously hypothesized and proven the therapeutic effects of hydrogen gas in graft-versus-host disease following stem cell transplantation. In the current manuscript, we present the clinical advances of hydrogen gas in hematological disorders.

Highlights

Hydrogen gas is the simplest molecule in nature which is formed by two hydrogen atoms
The first paper reported the biomedical ability of hydrogen gas was published in 1975 by Dole et al [2]
In 2001, Gharib et al further reported the antioxidative effect of hydrogen gas in vivo [4]

Summary

Introduction

Hydrogen gas is the simplest molecule in nature which is formed by two hydrogen atoms. In 2001, Gharib et al further reported the antioxidative effect of hydrogen gas in vivo [4] They reported that inhalation of 0.7 MPa H2 has therapeutic effects on schistosomiasis-associated chronic liver inflammation and thought the anti-inflammatory effects of hydrogen may be due to its scavenging hydroxyl radical ability. These papers do not attract too much attention until 2007, when Ohsawa et al demonstrated the selective antioxidative ability and therapeutic effects of hydrogen gas on cerebral ischemia [5]. We have carried out a clinical trial to further investigate the efficacy and safety of hydrogen on chronic GVHD (ClinicalTrials.gov number, NCT02918188)

Hemorrhage

Aplastic Anemia

Platelet Aggregation

Lymphoma

Findings

Conclusion