MEDICAL AND ECOLOGICAL ASPECTS OF ASSOCIATIONS BETWEEN HUMAN EXPOSURE TO TRACE CONCENTRATIONS OF STABLE BARIUM AND STRONTIUM AND FUNCTIONAL DISORDERS OF THE BODY. A REVIEW

Abstract

A systematic analysis of the published results of studies on the effect of trace elements such as barium (Ba) and strontium (Sr) on functional systems of the human body. With sufficient intake of stable Sr isotopes, a decrease in pulse arterial pressure is observed in the morning, associated with a decrease in mortality among patients with ischemic heart disease and arterial hypertension. There is a statistically significant linear relationship between the ratio of the Ba and Sr content in the hair and the circadian heart rate index, that is associated with an increase in the incidence of thrombosis, particularly during treatment with the Strontium ranelate at therapeutic doses. A statistically significant negative correlation was found between the Ba tissue concentrations and the increase in the patient's age that is also associated with an increase in the risk of progressive degenerative brain disorders, as well as chronic obstructive pulmonary disease. The possible association of Sr and Ba tissue concentrations in the body with the risk of Kashin-Beck disease is discussed. For early detection of this disease in the population residing endemic areas and the areas of its sporadic cases, it is advisable to evaluate the function of active flexion of the distal joints of II - IV fingers of the hands in people aged 4 to 26 years with imaging the bone structure of these fingers in the people at risk within acceptable doses of radiation.