Abstract
The present study aimed to examine the mediatory role of the dopaminergic system in the food intake induced by intracerebroventricular (ICV) injection of glycine in neonatal 3-h feed-deprived (FD3) meat-type chickens. In the first and second experiments, birds were ICV injected using low and high doses of glycine (50, 100 and 200nmol) and strychnine (50, 100 and 200nmol), respectively. In experiments 3-9, the behaviorally subeffective doses of dopamine (10nmol), 6-OHDA (2.5nmol), SCH 23,390 (D1 antagonist; 5nmol), AMI-193 (D2 antagonist; 5nmol), NGB2904 (D3 antagonist; 6.4nmol) and L-741,742 (D4 antagonist; 6nmol) were, respectively, co-administrated with glycine (200nmol) in FD3 5-day-old chicks to investigate possible interplay of dopamine receptors in glycine-induced feeding behavior. Then, cumulative food intake based on body weight percentage (%BW) was determined at 30, 60 and 120min after the injection. According to the results, dopamine significantly boosted the hypophagia induced by glycine at all-time intervals (p ≤ 0.001). These results combined with the previous findings suggest an interplay between dopamine and glycine in chicken's brain in which D1 receptor-mediated food intake induced by glycine.
Published Version
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